This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2304621-31-4
Purity:
98.54
Molecular Weight:
351.4
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)