This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1429179-07-6
Purity:
98.54
Molecular Weight:
436.48
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 µM, 0.072 µM and 1.38 µM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 µM[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)