This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1142363-52-7
Purity:
98.78
Molecular Formula:
C27H35N5O2
Molecular Weight:
461.6
Alternative Names:
JNJ-40346527; JNJ-527
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively[1]. Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimer’s disease and rheumatoid arthritis research[1][2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)