This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1808714-73-9
Purity:
99.16
Molecular Weight:
368.34
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)