Sitravatinib
Catalogue number:
HY-16961-10mg
Supplier:
Size:
10 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1123837-84-2
Purity:
99.59
Molecular Weight:
629.68
Alternative Names:
MGCD516; MG-516
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively[1]. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment[2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)