L-685458
Catalogue number:
HY-19369-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
292632-98-5
Purity:
99.37
Molecular Weight:
672.85
Alternative Names:
L-685,458
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers[1][2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)