£67.00
Estimated delivery Wed 7 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
64302-87-0
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
264.3
Alternative Names:
1-hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
- Data sheet: View or download
- MSDS: View or download
Product Description:
A GDH1 inhibitor (IC50 = 23 µM); decreases intracellular fumarate levels and increases mitochondrial ROS production in human H1299 lung and MDA-MB-231 breast cancer cells; inhibits proliferation in a panel of human cancer cell lines but not normal human cells from 10-40 µM; reduces tumor growth and intratumoral GDH1 activity in an H1299 mouse xenograft model at 20 mg/kg; reduces liver metastasis in a liver kinase B1-deficient lung cancer PDX mouse model
Storage Temperature:
-20°C