JX06
Catalogue number:
CAY34850-50 mg
Supplier:
Size:
50 mg
Product is available in:
£537.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
729-46-4
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
324.5
Alternative Names:
4,4′-(dithiodicarbonothioyl)bis-morpholine, nsc 402538
- Data sheet: View or download
- MSDS: View or download
Product Description:
An irreversible PDHK inhibitor (IC50s = 49, 101, and 313 nM for PDHK1, PDHK2, and PDHK3, respectively); selective for PDHK1-3 over PDHK4 (IC50 = >10 µM) and 322 other kinases at 10 µM but does inhibit FAK in a cell-free assay but not in a cell-based assay; increases ROS production and induces apoptosis in cancer cells with a high ECAR:OCR ratio; reduces the level of glycolysis metabolites in NCI H929 multiple myeloma cells at 0.25 µM; reduces tumor growth in an A549 mouse xenograft model
Storage Temperature:
-20°C