Norquetiapine
Catalogue number:
CAY36687-50 mg
Supplier:
Size:
50 mg
Product is available in:
£422.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
5747-48-8
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
295.4
Alternative Names:
11-(1-piperazinyl)-dibenzo[b,f][1,4]thiazepine, n-desalkylquetiapine
- Data sheet: View or download
- MSDS: View or download
Product Description:
An active metabolite of quetiapine; selectively inhibits NET (IC50 = 12 nM) over SERT and DAT (IC50s = 988 and >10,000 nM, respectively); binds to the histamine H1 receptor (Ki = 3.5 nM), as well as 5-HT1, 5-HT2, and 5-HT7, α1- and α2-adrenergic, dopamine D1-D5, and M1-M5 muscarinic receptors (Kis = 45-1,117 nM, 95-736, 196-1,419, and 23-453 nM, respectively); an antagonist at histamine H1, α1A- and α1D-adrenergic, M1, M3, and M5 muscarinic receptors in a concentration-dependent manner and an agonist at the 5-HT1A receptor (EC50 = 4,898 nM); reduces increases in immobility time in Vmat2 heterozygous mice at 0.1, 0.5, and 1 mg/kg
Storage Temperature:
-20°C