ER-819762
Catalogue number:
CAY10531-5 mg
Supplier:
Size:
5 mg
Product is available in:
£448.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1155773-15-1
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
489.7
Alternative Names:
(10s)-1′-[(3,5-dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methyl-spiro[1h-imidazo[1,5-b][2]benzazepine-1,4′-piperidin]-3(2h)-one
- Data sheet: View or download
- MSDS: View or download
Product Description:
An antagonist of EP4 (IC50 = 70 nM); selective for EP4 over EP1, EP2, and EP3 in a cAMP reporter assay at 10 µM; reduces differentiation of mouse helper T cells at 0.1 to 10 nM and decreases IL-23 secretion by mouse dendritic cells at 0.04 to 5 nM; reduces MDV levels in CEFs at 1 µM; prevents and reverses paw swelling, edema, and inflammation at 30 and 100 mg/kg in a mouse model of rheumatoid arthritis induced by GPI
Storage Temperature:
-20°C