SKLB23bb
Catalogue number:
CAY37242-1 mg
Supplier:
Size:
1 mg
Product is available in:
£239.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1815580-06-3
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
396.4
Alternative Names:
n-hydroxy-4-[2-methoxy-5-[methyl(2-methyl-4-quinazolinyl)amino]phenoxy]-butanamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of HDAC6 (IC50 = 17 nM); selective for HDAC6 over HDAC1-5 and HDAC7-11 (IC50s = 386->10,000 nM), inhibits tubulin acetylation in HeLa cervical cancer cells (EC50 = 58.9 nM) and the proliferation of A375 melanoma and HeLa cells (IC50s = 45 and 49 nM, respectively); inhibits microtubule formation in MDA-MB-231 cells; reduces tumor growth in HCT116, A2780, and MCF-7 mouse xenograft models from 12.5-50 mg/kg
Storage Temperature:
-20°C