Rhyncophylline
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76-66-4
≥98%
A crystalline solid
384.5
(αe,1′r,6′r,7′s,8′as)-6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-spiro[3h-indole-3,1′(5′h)-indolizine]-7′-acetic acid, methyl ester, mitrinermine, nsc 21731
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- MSDS: View or download
An alkaloid with diverse biological activities; inhibits arachidonic acid-, collagen-, or ADP-induced aggregation of isolated rabbit platelets (IC50s = 0.72, 0.74, and 0.67 mmol/L); decreases the number of sleep-wake cycles and increases total sleep time and REM sleep in rats at 0.25 mg/kg; reduces infarct volume and reverses sensory-motor and spatial memory defects in a mouse model of MCAO-induced stroke at 40 mg/kg; reduces hippocampal production of ROS and MDA levels and decreases escape latency in the Morris water maze test in a mouse model of Aβ42-induced Alzheimer’s disease
-20°C