This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1243245-18-2
Purity:
99.81
Molecular Formula:
C24H25FN6O2
Molecular Weight:
448.49
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. 1) GNF-6231 shows IC50s of greater than 10 µM on all CYP isoforms tested 2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration. 3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg. 4) GNF-6231 showed very robust dose-related antitumor efficacy.
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)