This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
219639-75-5
Purity:
98.6
Molecular Weight:
896.09
Alternative Names:
3D53
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC50 of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects[1][2][3][4][5][6].
Storage Temperature:
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)