GNE-490
Catalogue number:
HY-10812-1mg
Supplier:
Size:
1 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1033739-92-2
Purity:
96.29
Molecular Weight:
386.47
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K inhibitor with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model[1].
Storage Temperature:
4°C (Powder, protect from light)