This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2098191-53-6
Purity:
99.7
Molecular Weight:
487.55
Alternative Names:
eFT226
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex[1]. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM)[2]. Zotatifin induces cell apoptosis[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)