CDK12-IN-2
Catalogue number:
HY-112626-1mL
Supplier:
Size:
1 ml
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2244987-03-7
Purity:
99.44
Molecular Weight:
532.64
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)