This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1644626-43-6
Purity:
98.98
Molecular Weight:
591.83
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)