This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1551355-46-4
Purity:
99.51
Molecular Weight:
486.42
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Simmiparib is a highly potent and orally active PARP1 and PARP2 inhibitor with IC50 values of 1.75 nM and 0.22 nM, respectively. Simmiparib has more potent PARP1/2 inhibition than its parent Olaparib (HY-10162). Simmiparib induces DNA double-strand breaks (DSB) accumulation and G2/M arrest in homologous recombination repair (HR)-deficient cells, thereby inducing apoptosis. Simmiparib exhibits remarkable anticancer activities in cells and nude mice bearing xenografts[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)