TP0427736 (hydrochloride)
Catalogue number:
HY-118528A-25mg
Supplier:
Size:
25 mg _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2459963-17-6
Purity:
98.28
Molecular Formula:
C14H11ClN4S2
Molecular Weight:
334.85
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)