This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
195529-54-5
Purity:
99.85
Molecular Weight:
558.66
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. The selectivity of A-192621 is 636-fold higher than ETA (IC50 of 4280 nM and Ki of 5600 nM). A-192621 promotes apoptosis in PASMCs. A-192621 alos causes elevation of arterial blood pressure and an elevation in the plasma ET-1 level[1][2][3].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)