This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1456858-57-3
Purity:
99.92
Molecular Weight:
469.58
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively[1]. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells[2]. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370[3].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)