This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
922150-12-7
Purity:
99.94
Molecular Weight:
592.56
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53R175H, p53R248W and p53R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research[1].
Storage Temperature:
4°C (Powder, stored under nitrogen)