This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1262857-73-7
Purity:
99.22
Molecular Weight:
449.4
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E[1][2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)