This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2080410-41-7
Purity:
98.66
Molecular Weight:
410.44
Alternative Names:
DDD01305143
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 µM for WT L. donovani proteasomes). GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC50: purified 26S=13 µM; enriched THP-1 extracts IC50=40µM). GSK3494245 exhibits attractive biological and biosafety properties[1][2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)