PROTAC PD-1/PD-L1 degrader-1
Catalogue number:
HY-131183-5mg
Supplier:
Size:
5 mg _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2447066-37-5
Purity:
98.35
Molecular Formula:
C59H58ClN7O11
Molecular Weight:
1076.59
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner[1].
Storage Temperature:
-20°C (Powder, sealed storage, away from moisture and light)