BMS-1166-N-piperidine-COOH
Catalogue number:
HY-131187-50mg
Supplier:
Size:
50 mg _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2447066-00-2
Purity:
97.26
Molecular Formula:
C37H35ClN2O6
Molecular Weight:
639.14
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1[1]. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[2].
Storage Temperature:
-20°C (Powder, sealed storage, away from moisture and light)