ZX-29
Catalogue number:
HY-135887-25mg
Supplier:
Size:
25 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2254805-62-2
Purity:
99.52
Molecular Weight:
518.03
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect[1].
Storage Temperature:
4°C (Powder, protect from light)