This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2262488-39-9
Purity:
98.44
Molecular Weight:
451.94
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
S2157, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2157 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood-brain barrier and can almost completely eradicate CNS leukemia in mice transplanted with T-ALL cells[1].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)