This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2229711-68-4
Purity:
99.6
Molecular Weight:
723.9
Alternative Names:
ARV-471
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Vepdegestrant (ARV-471) is an oral estrogen receptor PROTAC protein degrader for breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of ~2 nM[1].
Storage Temperature:
-20°C (Powder, sealed storage, away from moisture and light)