This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2035089-28-0
Purity:
99.18
Molecular Weight:
539.67
Alternative Names:
SH-1028
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Oritinib (SH-1028), an irreversible third-generation EGFR TKI, overcomes T790M-mediated resistance in non-small cell lung cancer. Oritinib (SH-1028), a mutant-selective inhibitor of EGFR kinase activity, inhibits EGFRWT, EGFRL858R, EGFRL861Q, EGFRL858R/T790M, EGFRd746-750 and EGFRd746-750/T790M kinases, with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM, respectively[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)