Anti-Mesothelin CAR Lentivirus (P4 ScFv-CD8-4-1BB-CD3ζ)
The Anti-mesothelin CAR lentiviruses are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv (single-chain fragment variable) of anti-mesothelin (Clone P4) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1).
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Figure 1. (A) Schematic of the lenti-vector used to generate the anti-mesothelin CAR lentivirus and (B) Construct diagram showing components of the anti-mesothelin CAR.
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![image 0](https://www.bioscience.co.uk/product_images/BPS/__682099.78703_2.jpg)
![image 1](https://www.bioscience.co.uk/product_images/BPS/__682100.78703_3_1.jpg)
![image 2](https://www.bioscience.co.uk/product_images/BPS/__682101.78703_4_1.jpg)
Lentiviruses are shipped with dry ice. For long term storage, it is recommended to store the virus a