Clasto-lactacystin β-lactone
Catalogue number:
BPS-27224
Supplier:
Size:
50 µg _$$_
Product is available in:
N/A
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CAS Number:
154226-60-5
Purity:
≥98% by HPLC
Molecular Formula:
C10H15NO4
Molecular Weight:
213.2
Alternative Names:
Omuralide
- Data sheet: View or download
Product Description:
Clasto-lactacystin β-lactone, also known as Omuralide and β-Clastolactacystin, targets ubiquitins. It is an active metabolite of lactacystin which induces differentiation and inhibition of cell cycle progression in several tumor cell lines. The inhibitor irreversibly alkylates subunit X of the 20s proteasome. Inhibition of proteasome peptidase activity results in the accumulation of various ubiquitinated proteins which normally undergo rapid degredation. Therefore, the effects are pleiotropic and largely depend on the expression patter of signaling proteins within the treated cell.
