CAS Number:
129-56-6
Purity:
≥99%
Molecular Weight:
220.2
Product Description:
Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki = 0.19 µM). SP600125 is an ATP-competitive reversible inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocked the activation and differentiation of primary human CD4 cell cultures.
Storage Temperature:
Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored a