Melagatran
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159776-70-2
≥90%
A solid
429.5
n-[(1r)-2-[(2s)-2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-glycine
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- MSDS: View or download
A thrombin inhibitor and an active metabolite of ximelagatran (Ki = 0.002 µM); selective for thrombin over a variety of serine proteases (Kis = 0.6-10.2 µM) but also inhibits trypsin (Ki = 0.004 µM); inhibits thrombin-induced aggregation of isolated washed human platelets (IC50 = 1.9 nM); decreases the dry weight of thrombi in rats (ED50 = 16 µg/kg); increases total bleeding time and blood loss in rats (ID50s = 300 and 6.8 µg/kg, respectively); reduces brain infarct volume and increases blood reperfusion alone and in combination with tPA in a rat model of ischemia-induced TBI at 5 µmol/kg per hour
-20°C