Tazemetostat
Catalogue number:
HY-13803-10mg
Supplier:
Size:
10 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1403254-99-8
Purity:
99.93
Molecular Formula:
C34H44N4O4
Molecular Weight:
572.74
Mass Spectrometry:
Reference Materials
Alternative Names:
EPZ-6438; E-7438
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells[1].