Isoliquiritigenin
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961-29-5
≥98%
A crystalline solid
256.3
1-(2e,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, gu 17, ilq, isl
- Data sheet: View or download
- MSDS: View or download
A flavonoid with diverse biological activities; reduces tumor growth in an NCI-H1975 NSCLC mouse xenograft model at 1 and 5 mg/kg; inhibits hepatic steatosis and prevents increases in hepatic TBARS, iNOS, and COX-2 levels in mice fed a high-fat diet at 10 mg/kg per day; inhibits LPS-induced increases in IL-1β and IL-6 levels in J774A.1 murine macrophages (IC50s = 7.2 and 7.16 µM, respectively); reduces gastric acid secretion and gastric ulcer formation in pylorus-ligated rats at 5 and 10 mg/kg; an ERα and ERβ agonist (IC50s = 16 and 7.8 µM, respectively); induces estrogen-responsive alkaline phosphatase activity in Ishikawa endometrial cancer cells (EC50 = 2.7 µM); a histamine H2 receptor and LXRα antagonist
-20°C
