Celecoxib
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169590-42-5
≥98%
A crystalline solid
381.4
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1h-pyrazol-1-yl]-benzenesulfonamide, sc-58635, ym-177
- Data sheet: View or download
- MSDS: View or download
An NSAID and a COX-2 inhibitor (IC50 = 0.05 µM); selective for COX-2 over COX-1 (IC50 = 22.9 µM); induces apoptosis in BJAB and Jurkat cancer cells in a concentration-dependent manner; reduces blood glucose levels in a rat model of diabetes induced by STZ; reduces the latency to escape and the path length in the Morris water maze and also increases BDNF and TrkB protein levels in the hippocampus in the same model; inhibits production of IL-1β and TNF-α and reduces synovial fluid expression of the gene encoding MMP-3 in a rabbit model of osteoarthritis; increases serum levels of LDH, troponin-T, TNF-α, and CK-MB, markers of cardiotoxicity, in rats at 100 mg/kg per day
-20°C