Doxepin (hydrochloride)
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1229-29-4
≥95%
A crystalline solid
315.8
3-(dibenz[b,e]oxepin-11(6h)-ylidene)-n,n-dimethyl-1-propanamine, monohydrochloride
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- MSDS: View or download
A tricyclic antidepressant; binds to SERT and NET (Kds = 68 and 29.5 nM, respectively); a histamine H1 receptor antagonist (Ki = 1.23 nM); selectively binds to SERT and NET over DAT (Kd = 12,100 nM) and inhibits histamine H1 over H2, H3, and H4 receptors (Kis = 170, 39,810, and 15,135 nM, respectively); binds to the 5-HT2 receptor, as well as to muscarinic acetylcholine and α1-ARs (Kds = 27, 23, and 23.5 nM, respectively); decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain at 10 mg/kg, i.p.; increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress at 15 mg/kg
-20°C
