Clonidine (hydrochloride)
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4205-91-8
≥98%
A crystalline solid
266.6
n-(2,6-dichlorophenyl)-4,5-dihydro-1h-imidazol-2-amine, monohydrochloride, st 155
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- MSDS: View or download
An α2-AR agonist (Kis = 61.66, 69.18, and 134.9 nM for α2A-, α2B-, and α2C-ARs, respectively); stimulates [35S]GTPγS binding to HEK293 cell membranes expressing human receptors (EC50s = 26.92, 56.23, and 912.01 nM for α2A-, α2B-, and α2C-ARs, respectively); binds to I1-imidazoline sites in a variety of cell and tissue types (Kds = 4-15 nM); induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine at 10 µM; induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings at 10 µM; reduces mean blood pressure and heart rate when administered via microinjection to the NRL of anesthetized normotensive cats at 0.1 and 1 µg/kg
-20°C
