AZD 9291
Shipping is calculated in checkout
1421373-65-0
≥98%
A crystalline solid
499.6
n-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide, osimertinib
- Data sheet: View or download
- MSDS: View or download
An inhibitor of mutant EGFRs (IC50s = 1, 12, and 5 nM for EGFRL858R/T790M, EGFRL858R, and EGFRL861Q, respectively); selective for these mutant EGFRs over wild-type EGFR (IC50 = 184 nM), as well as over a panel of approximately 280 other kinases at 1 µM; selectively inhibits the proliferation of NSCLC cells containing activating and/or resistant mutants of EGFR (IC50s = 8-40 nM) over wild-type EGFR-containing Calu-3 and NCI H2073 NSCLC cells (IC50s = 650 and 461 nM, respectively); induces tumor regression in a vandetanib-resistant PC-9 NSCLC mouse xenograft model at doses ranging from 1-10 mg/kg
-20°C
