Phenoxybenzamine (hydrochloride)
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63-92-3
≥98%
A crystalline solid
340.3
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzenemethanamine, monohydrochloride, nsc 37448
- Data sheet: View or download
- MSDS: View or download
An α-AR antagonist; inhibits norepinephrine-induced inositol phosphate formation in HEK293 cells expressing α1-ARs (EC50s = 125.9-316.2 nM), as well as radioligand binding to α2A-, α2B-, and α2C-ARs in CHO cell membranes (Kis = 60, 10, and 60 nM, respectively); decreases norepinephrine-, histamine-, and calcium-induced contractions in isolated rabbit aortic strips from 0.5-5 µM; inhibits proliferation of a variety of cancer cell lines (IC50s = 29.5-99.8 µM); reduces cirazoline-, St-587-, Sgd 101/75-, and B-HT 920-induced increases in diastolic blood pressure in pithed rats; decreases the time to find the platform in the Morris water maze, indicating restored spatial memory, in a rat model of fluid percussion-induced TBI
-20°C
