Rosiglitazone (maleate)
Catalogue number:
CAY11884-1 g
Supplier:
Size:
1 g
Product is available in:
£244.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
155141-29-0
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
473.5
Alternative Names:
5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, (2z)-2-butenedioate (1:1), brl 49653c
- Data sheet: View or download
- MSDS: View or download
Product Description:
A PPARγ agonist; activates PPARγ1 and PPARγ2 in reporter assays (EC50s = 30 and 100 nM, respectively); selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 mM; an inhibitor of ACSL4 (IC50 = 0.5 µM), inhibits RSL3-induced ferroptosis in Pfa1 cells and Pparg KO cells, and increases survival in a Gpx4 KO mouse model of ferroptosis at 0.0125 mg/ml in the drinking water; decreases HbA1c and fasting blood glucose levels in a rat model of type 2 diabetes induced by STZ and a high-carbohydrate and high-fat diet at 4 mg/kg
Storage Temperature:
-20°C
