Metamizole (sodium salt)
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68-89-3
≥98%
A crystalline solid
333.3
1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1h-pyrazol-4-yl)methylamino]-methanesulfonic acid, monosodium salt, dipyrone
- Data sheet: View or download
- MSDS: View or download
A nonopioid prodrug; inhibits COX-1 and COX-2 activity (IC50 = ~150 µg/ml for both in cell-free assays), as well as reduces AITC-induced increases in intracellular calcium levels in isolated rat and mouse dorsal root ganglia and IMR-90 human fibroblasts (IC50s = 30-91 µM in patch-clamp assays); inhibits ADP- and epinephrine-induced platelet aggregation in hPRP; prevents fever induced by LPS, TNF-α, and IL-6, but not arachidonic acid or PGE2, in rats at 120 mg/kg; increases the paw withdrawal threshold in the paw pressure test in rat models of carrageenan-induced acute pain and postoperative incision pain at 250 and 500 mg/kg
-20°C
