ONX 0914
Catalogue number:
CAY16271-5 mg
Supplier:
Size:
5 mg
Product is available in:
£216.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
960374-59-8
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
580.7
Alternative Names:
n-[2-(4-morpholinyl)acetyl]-l-alanyl-o-methyl-n-[(1s)-2-[(2r)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-l-tyrosinamide, pr-957
- Data sheet: View or download
- MSDS: View or download
Product Description:
A selective inhibitor of the β5i (LMP7) subunit of the immunoproteasome (IC50s = 65 and 73 nM for mouse and human, respectively) that demonstrates significantly weaker activity at the β5 subunit of the constitutive proteasome (IC50s = 0.92 and 1.04 µM for mouse and human, respectively); blocks the production of proinflammatory cytokines and inhibits TH1 and TH17 cell differentiation; attenuates disease progression in several experimental models of autoimmune disorders as well as in some hematologic malignancies
Storage Temperature:
-20°C
