Apamin (trifluoroacetate salt)
Shipping is calculated in checkout
24345-16-2
≥95%
A solid
2027.3
l-cysteinyl-l-asparaginyl-l-cysteinyl-l-lysyl-l-alanyl-l-prolyl-l-α-glutamyl-l-threonyl-l-alanyl-l-leucyl-l-cysteinyl-l-alanyl-l-arginyl-l-arginyl-l-cysteinyl-l-glutaminyl-l-glutaminyl-l-histidinamide, cyclic (1→11),(3→15)-bis(disulfide), trifluoroacetate
- Data sheet: View or download
- MSDS: View or download
An inhibitor of KCa2.2/SK2 channels (IC50s = 0.06-0.4 nM); selective for KCa2.2/SK2 channels over KCa2.1/SK1 and KCa2.3/SK3 channels (IC50s = 1-12 and 1-13 nM, respectively), as well as KCa3.1/SK4 channels at 1 µM but does inhibit Kv1.3 (IC50 = 13 nM); reduces CD8+ cell infiltration into the CNS and EAE severity, as well as increases peripheral blood levels of CD62L-, CD44L-, and CD44+ memory T cells, in mice; has commonly been used to determine the role of KCa/SK channels in various cells and tissues
-20°C
