BQ-788 (sodium salt)
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156161-89-6
≥95%
A solid
664.8
n-[[(2r,6s)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-l-leucyl-1-(methoxycarbonyl)-d-tryptophyl-d-norleucine, monosodium salt
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- MSDS: View or download
A peptide ETB receptor antagonist (IC50 = 1.2 nM); selective for ETB over ETA receptors (IC50 = 280 nM), as well as angiotensin, calcitonin, or neuropeptide receptors at 10 µM; inhibits ET-1-induced calcium mobilization in human Girrardi heart cells (IC50 = 0.54 nM) and BQ-3020-induced vasoconstriction in isolated rat pulmonary arteries (pA2 = 8.4); inhibits ET-1 induced depressor responses and induces pressor responses in rats at 1 mg/kg; protects against laparotomy and surgical gut handling-induced inhibition of intestinal motility in rats; attenuates delayed hypotension, vascular hyporeactivity to norepinephrine, and hepatocellular injury and dysfunction in a rat model of LPS-induced endotoxemi
-20°C
