(5Z)-7-Oxozeaenol
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253863-19-3
≥99%
A solid
C19H22O7
362.4
(3s,5z,8s,9s,11e)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1h-2-benzoxacyclotetradecin-1,7(8h)-dione, fr148083, l-783,279, ll-z 1640-2
- Data sheet: View or download
- MSDS: View or download
A TAK1 inhibitor (IC50 = 8.1 nM in the presence of TAB1); selective for TAK1 over MEK1 and MEKK1 (IC50s = 411 and 268 nM, respectively), as well as ASK1 and IKKβ at 300 nM; inhibits NF-κB activity in a reporter assay using HEK293 cells expressing TAK1 and TAB1 (IC50 = 83 nM); reduces IL-1-induced increases in COX-2 levels in MEFs; sensitizes HeLa cells to TRAIL-induced apoptosis at 300 nM; induces necroptosis when used in combination with TNF and zVAD in primary mouse BMDMs at 100 nM; topical application prevents picryl chloride-induced increases in ear thickness in mice
-20°C
