SP600125
Catalogue number:
SM41-10
Supplier:
Size:
10 mg
Product is available in:
CAS Number:
129-56-6
Purity:
>99%
Molecular Weight:
220.23
- Data sheet: View or download
- MSDS: View or download
Product Description:
SP600125 is a potent, selective and reversible inhibitor of the three JNK enzymes (c-Jun N-terminal kinases). Inhibition is competitive with respect to ATP, and over 300-fold more selective for JNK as compared to ERK1 and p38-2 MAP kinases. SP600125 was shown to cause a dose-dependent inhibition of the phosphorylation of c-Jun, and thereby the expression of inflammatory genes COX-2, IFN-gamma, IL-2 and TNF-alpha.
