Ifenprodil (hemitartrate)
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23210-58-4
≥98%
A crystalline solid
400.5
α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidineethanol, 2r,3r-dihydroxybutanedioate (2:1), np-120
- Data sheet: View or download
- MSDS: View or download
A selective antagonist of NR1A/NR2B subunit-containing NMDA receptors (IC50 = 340 nM); selective for NR1A/NR2B subunit-containing NMDA receptors over those containing NR1A/NR2A or NR1A/NR2C subunits (IC50s = 20 and >100 µM, respectively); binds to σ1 receptors, emopamil binding protein, and fungal C-8 sterol isomerase/ERG2 (Kis = 2, 5, and 1 nM, respectively), as well as α1-ARs (IC50 = 110 nM), 5-HT1A and 5-HT2 (IC50s = 238 and 610 µM, respectively); inhibits infection of MDCK cells by H1N1 and H3N2 influenza isolates in vitro (EC50s = 6.6 and 16.9 µM, respectively); increases NGF, BDNF, and GDNF production in primary mouse astrocytes at 150 µM; reduces maximal electroshock seizures in mice (ED50s = 16 and 7 mg/kg, respectively)
-20°C
